Alison's great-grandfather, James McLain Millikan was a R.R. agent in Sabina. We're thinking that maybe he's in this photo? His brother, Joseph Millikan, was an R.R. agent in Washington C.H. This photo has been handed down through the family.
The map thumbnail to the left is from Sabina in 1876 (click for larger image). It shows the location of the "Depot." As far as I can tell this building no longer exists. (Thanks to www.historicmapworks.com for the online maps!)
The following information is from p.95 of History of Clinton County, Ohio, 1915:
On August 15, 1853, trains began running regularly between Cincinnati and Wilmington, one a day each way. The fare between the points was one dollar and sixty cents. The road was completed to Washington C. H., Fayette county, November 24, 1553, and the company began to run its trains to that point, forty-one and one-half miles to Morrow, and seventy-seven and one-half miles from Cincinnati. The road was finished to Lancaster in 1854 and the same year the contract was let for building the part between Lancaster and Zanesville. This part of the road was not finished until late in 1855, but by 1856 trains were running uninterruptedly over the entire length of the road.
Click on a person below to get a close-up view. Here's a high-resolution scan of the photo.